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Lude Franke

Statistical geneticist, department of genetics, University Medical Centre Groningen

Session

11:30 - 12:45
From general to personalized

Lude Franke is associate professor of systems genetics at the University Medical Center Groningen. His group focuses on the development and application of novel statistical and computational methods to very large datasets to better understand what key genes, pathways and cell-types are causally disrupted in disease. Paradoxically, he is doing this by using data from healthy individuals: by using genetic variation and integrating this with multi-omics datasets, his group can identify pathways and cell-types that play important roles in disease, some of which might the targeted pharmaceutically.

Abstract

Using big-data to identify personalised drug targets 
With the availability of new techniques, such as single-cell sequencing, huge amounts of data are now becoming available. But how can you reuse this previously generated data for other purposes? In this presentation I will discuss new strategies how to recycle ‘big data’ and show that by integrating different types of data it is possible to identify novel drug targets for disease that might be strongly personalised.
Niels Chavannes
LUMC
Maarten van Dongen
LabForRent
Ingmar de Gooijer
myTomorrows
Mark van Houdenhoven
Sint Maartenskliniek

Henk van Houten
Philips

Arthur Lahr
Kiadis Pharma

Jos Malda
UMC Utrecht
Eveliene Manten-Horst
AYA Jongvolwassen & Kanker

Madelon Maurice
UMC Utrecht

Tom Miller
GreyBird Ventures
Edwin Moses
Ablynx
Kees Recourt
Mibiton Foundation

Maurits van Selms
ACTA

Marianne van der Steen
MERLN
Markwin Velders
Kite Pharma
Werner Verbiest
Janssen Diagnostics
Eline Vrijland-van Beest
NightBalance
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