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Lude Franke

Statistical geneticist, department of genetics, University Medical Centre Groningen

Session

11:30 - 12:45
From general to personalized

Lude Franke is associate professor of systems genetics at the University Medical Center Groningen. His group focuses on the development and application of novel statistical and computational methods to very large datasets to better understand what key genes, pathways and cell-types are causally disrupted in disease. Paradoxically, he is doing this by using data from healthy individuals: by using genetic variation and integrating this with multi-omics datasets, his group can identify pathways and cell-types that play important roles in disease, some of which might the targeted pharmaceutically.

Abstract

Using big-data to identify personalised drug targets 
With the availability of new techniques, such as single-cell sequencing, huge amounts of data are now becoming available. But how can you reuse this previously generated data for other purposes? In this presentation I will discuss new strategies how to recycle ‘big data’ and show that by integrating different types of data it is possible to identify novel drug targets for disease that might be strongly personalised.

Kees Been
Lysosomal Therapeutics Inc.

Erik van de Berg
AM-Pharma

René Bernards
Qameleon Therapeutics & NKI

Annelien Bredenoord
UMC Utrecht

Carine van den Brink
AXON Lawyers

Danielle Curfs
Chemelot InSciTe
Jenny Dankelman
TU Delft
Diederik Dippel
Erasmus MC

Cornelia van Duijn
Erasmus MC

Lude Franke
UMCG
Thibault Helleputte
DNAlytics
Mark van Houdenhoven
St. Maartenskliniek
Henk Joos
Flanders Bio
Peter de Keizer
Erasmus MC
Tim Knotnerus
AM-Pharma, PRIMER Professionals
Angus Livingstone
Oncode Institute
Travis McCready
Massachusetts Life Sciences Center

Mirjam Mol
Pivot Park

Barend Mons
DTL & LUMC
Timothy Noël
Eindhoven University of Technology
Jacquelien Noordhoek
Dutch CF Foundation
Violet Petit-Steeghs
Athena Institute
Thomas Plochg
NPHF
Dirk Jan van der Pol
Ordina
Anne Portwich
LSP
Elisabeth van Rossum
Erasmus MC
André van de Sande
Xendo
Marlies Schijven
AMC
Hans Schikan
Topsector LSH
Hanneke Schuitemaker
Janssen Vaccines
Frits Schut
V.O. Patents & Trademarks
Marieke Schuurmans
UMC Utrecht
Jacob Seidell
VU
Agaath Sluijter
Medical Delta
Thijs Spigt
Erasmus MC
Marianne van der Steen
Maastricht University
Maarten Steinbuch
Eindhoven University of Technology
Onno van de Stolpe
Galapagos
Werner Verbiest
Janssen Diagnostics
Martine de Vries
LUMC

Edward van Wezel
BioGeneration Ventures

Jan van de Winkel
Genmab

Loek Winter
DC Klinieken

Hanneke Heeres
Health~Holland
Caroline Duterloo
Medical Delta
Paul Korte
Janssen
Aart Jan van der Lelij
Erasmus MC
Werner Brouwer
Erasmus University
Arnout van Diermen
Novo Nordisk

Ton van der Steen
Erasmus MC & Medical Delta

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