Innovation for Health - 14 February 2019
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Innovation for Health - Shaping the future of healthcare
Innovation for Health - Shaping the future of healthcare
Innovation for Health - Shaping the future of healthcare

Paul Vulto

Managing Director & Co-Founder, Mimetas
Paul Vulto

Session

14:45 - 16:00
Impact of innovation on regulatory sciences

Paul Vulto is CEO and co-founder of MIMETAS. Under his guidance, MIMETAS developed into a multinational company with operations in Europe, US and Japan. MIMETAS currently works with the majority of top-50 pharma companies and counts over 85 co-workers. Paul is the inventor behind the OrganoPlate® platform and PhaseGuide technology of MIMETAS. Prior to founding MIMETAS, Paul worked for the high-tech company Silicon Biosystems in Bologna, the Institute for Microsystems Engineering (IMTEK) at the University of Freiburg and the Leiden Academic Centre for Drug Research, Leiden University. Paul holds a cum Laude masters degree in Electrical Engineering and a cum Laude PhD degree in Microsystems Engineering.

Abstract

Organ-on-a-Chip technology as a routine tool in drug discovery and development
Organ-on-a-Chip technology is a new paradigm in drug testing. The technology has as its aim to raise the physiological relevance of traditional cell culture by combining this with microfluidic techniques. Organs-on-a-Chip are 3D tissues that capture the complexity of in vivo tissues including 3D morphology, extracellular matrix embedment, multiple cell types, vascular structure and perfusion flow.

In this presentation I will introduce culture and interrogation of complex 3D tissues, such as liver, kidney, gut and brain tissue. The tissues are grown on the OrganoPlate® platform [1, 2, 3], that allow culturing of over 40 tissues in parallel. The tissues are embedded in an extracellular matrix gel and comprise both stromal tissue, bloodvessel structures as well as epithelial barriers with clear apical and basal sides. The platform can be interrogated using automated imaging equipment as well as all standard equipment including fluorescence-based assays, immunohistochemical staining, barrier integrity monitoring, transport studies, viability assays, qRT-PCR, ELISA’s and many others. Last but not least, operation of the platform is thus straightforward that an end-user who is not necessarily an expert in the field of microfluidics is able to perform the study. In this presentation I will show examples of Organ-on-a-Chip tissues for use in drug safety testing and disease modelling.

[1] S J Trietsch, M C Setyawati, M K Vormann, K J Wilschut, H L Lanz, A Nicholas, C P Ng, D Kurek, J Joore, S Kustermann, A Roth, T Hankemeier, A Moisan, P Vulto, Perfused intestinal tubules for real-time assessment of drug-induced barrier disruption, Nature communications 2017, 8 (1), 262
[2] V. van Duinen, A. van den Heuvel, S.J. Trietsch, H.L. Lanz, J.M van Gils, A.J. van Zonneveld, P. Vulto, T. Hankemeier, 96 perfusable blood vessels to study vascular permeability in vitro, Scientific reports, 2017, 7 (1), 18071
[3] Nienke R. Wevers, Remko van Vught, Karlijn J. Wilschut, Arnaud Nicolas, Chiwan Chiang, Henriette L. Lanz, Sebastiaan J. Trietsch, Jos Joore, Paul Vulto, Drug candidate evaluation on 3D networks of neurons and glia in a microfluidic platform, Scientific Reports 2016, 6, 38856

Henk van Houten
Royal Philips

Henk van Houten
Edwin Moses
Ablynx
Edwin Moses

Peter Paul van Benthem
Dutch Association of Medical Specialists

Peter Paul van Benthem
Niels Chavannes
LUMC
Niels Chavannes

Madelon Maurice
UMC Utrecht & Oncode Institute

Madelon Maurice
Ingmar de Gooijer
myTomorrows
Ingmar de Gooijer
Tom Miller
GreyBird Ventures
Tom Miller
Mark van Houdenhoven
Sint Maartenskliniek
Mark van Houdenhoven
Ruben Kok
Dutch Techcentre for Life Sciences
Ruben Kok
Colja Laane
Mibiton
Colja Laane

Arthur Lahr
Kiadis Pharma

Arthur Lahr
Eveliene Manten-Horst
AYA Jongvolwassen & Kanker
Eveliene Manten-Horst
Kas Maessen
NWO Science domain
Kas Maessen
Eline Vrijland-van Beest
NightBalance
Eline Vrijland-van Beest
Jos Malda
UMC Utrecht
Jos Malda
Lucien Hordijk
Investigative reporter
Lucien Hordijk
Maarten van Dongen
LabForRent
Maarten van Dongen
Kees Recourt
Mibiton Foundation
Kees Recourt

Maurits van Selms
ACTA

Maurits Selms
Marianne van der Steen
MERLN
Marianne van der Steen
Werner Verbiest
Janssen Diagnostics
Werner Verbiest
Peter Hinssen
nexxworks
Peter Hinssen
Markwin Velders
Kite Pharma
Markwin Velders
Nicolas Vergauwe
miDiagnostics
Nicolas Vergauwe

Marc Schellekens
LabHotel Rotterdam

Marc Schellekens
Bert-Arjan Millenaar
NLC | The Healthtech Venture Builder
Bert-Arjan Millenaar
Phil L'Huillier
MSD
Carine van den Brink
AXON Lawyers
Carine van den Brink
Jeff Gielen
Kadans Science Partner
Jeff Gielen
Annemiek Verkamman
HollandBIO
Ton van der Steen
Erasmus MC Medical Delta
Hans Schikan
Health~Holland
Joke Boonstra
Erasmus MC
Joke Boonstra
Ton de Boer
Medicines Evaluation Board
Anthonius de Boer
Onno van de Stolpe
Galapagos
Onno van de Stolpe
Joep de Groot
CbusineZ
Joep de Groot
Wietske Vrijland
Maasstad Hospital
Wietske Vrijland
Kurt Hertogs
Graphene.Works
Kurt Hertogs

Vladan Ilić
Westerdokters

Vladan Ilić

Zoraide Granchi
GenomeScan

Zoriade Granchi
Bert Leufkens
Utrecht University
Bert Leufkens
Chris van Hoof
imec
Chris van Hoof
Wiek van Gilst
UMCG
Wiek van Gilst
Stefan Braam
Ncardia
Stefan Braam
Paul Vulto
Mimetas
Paul Vulto
Rik Vos
Erasmus MC
Rik Vos
Maaike Kleinsmann
TU Delft
Maaike Kleinsmann
Frank van Visseren
UMC Utrecht
Frank van Visseren
Eva van Rooijen
NLC | The Healthtech Venture Builder
Eva van Rooijen
Claudia Wieringa
MSD
Paul Korte
Janssen & Vereniging Innovatieve Geneesmiddelen

Thomas Plochg
NPHF

Marcel van Raaij
Ministerie VWS

Kurt Gielen
Medace

Martijn Busstra
Erasmus MC
Sponsors & Partners
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Health~Holland
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Erasmus MC
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Gemeente Rotterdam
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Life Sciences & Health 010
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MSD
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Janssen Diagnostics - Janssen
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Medical Delta
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NLC The Healthtec Venture Builder
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