Innovation for Health - 13 February 2020
Contact Investor Forum I4H Bootcamp
Innovation for Health - Shaping the future of healthcare

Paul Vulto

Managing Director & Co-Founder, Mimetas
Paul Vulto


14:45 - 16:00
Impact of innovation on regulatory sciences

Paul Vulto is CEO and co-founder of MIMETAS. Under his guidance, MIMETAS developed into a multinational company with operations in Europe, US and Japan. MIMETAS currently works with the majority of top-50 pharma companies and counts over 85 co-workers. Paul is the inventor behind the OrganoPlate® platform and PhaseGuide technology of MIMETAS. Prior to founding MIMETAS, Paul worked for the high-tech company Silicon Biosystems in Bologna, the Institute for Microsystems Engineering (IMTEK) at the University of Freiburg and the Leiden Academic Centre for Drug Research, Leiden University. Paul holds a cum Laude masters degree in Electrical Engineering and a cum Laude PhD degree in Microsystems Engineering.


Organ-on-a-Chip technology as a routine tool in drug discovery and development
Organ-on-a-Chip technology is a new paradigm in drug testing. The technology has as its aim to raise the physiological relevance of traditional cell culture by combining this with microfluidic techniques. Organs-on-a-Chip are 3D tissues that capture the complexity of in vivo tissues including 3D morphology, extracellular matrix embedment, multiple cell types, vascular structure and perfusion flow.

In this presentation I will introduce culture and interrogation of complex 3D tissues, such as liver, kidney, gut and brain tissue. The tissues are grown on the OrganoPlate® platform [1, 2, 3], that allow culturing of over 40 tissues in parallel. The tissues are embedded in an extracellular matrix gel and comprise both stromal tissue, bloodvessel structures as well as epithelial barriers with clear apical and basal sides. The platform can be interrogated using automated imaging equipment as well as all standard equipment including fluorescence-based assays, immunohistochemical staining, barrier integrity monitoring, transport studies, viability assays, qRT-PCR, ELISA’s and many others. Last but not least, operation of the platform is thus straightforward that an end-user who is not necessarily an expert in the field of microfluidics is able to perform the study. In this presentation I will show examples of Organ-on-a-Chip tissues for use in drug safety testing and disease modelling.

[1] S J Trietsch, M C Setyawati, M K Vormann, K J Wilschut, H L Lanz, A Nicholas, C P Ng, D Kurek, J Joore, S Kustermann, A Roth, T Hankemeier, A Moisan, P Vulto, Perfused intestinal tubules for real-time assessment of drug-induced barrier disruption, Nature communications 2017, 8 (1), 262
[2] V. van Duinen, A. van den Heuvel, S.J. Trietsch, H.L. Lanz, J.M van Gils, A.J. van Zonneveld, P. Vulto, T. Hankemeier, 96 perfusable blood vessels to study vascular permeability in vitro, Scientific reports, 2017, 7 (1), 18071
[3] Nienke R. Wevers, Remko van Vught, Karlijn J. Wilschut, Arnaud Nicolas, Chiwan Chiang, Henriette L. Lanz, Sebastiaan J. Trietsch, Jos Joore, Paul Vulto, Drug candidate evaluation on 3D networks of neurons and glia in a microfluidic platform, Scientific Reports 2016, 6, 38856
Dharminder Chalal
Marcel Levi
University College London Hospitals
Michel Dumontier
Maastricht University
Thijn Brummelkamp
Scenic Biotech
Hans Schikan
Topsector Life Sciences & Health
Inge Huitinga
Netherlands Brain Bank
Sjaak Vink
Annemarie Jorritsma
Wiro Niessen
Erasmus MC, TU Delft & Quantib
Tim Knotnerus
AgomAb Therapeutics
Elise Meijer
Antwerp Management School & Accenture Strategy
Esther Talboom-Kamp
Saltro Diagnostics
Joep Muijrers
PureTech Health
Els Beirnaert
Aelin Therapeutics
Carine van den Brink
Axon Lawyers

Claudia Rijcken

Rajiv Vaid Basaiawmoit
Aarhus University & Biosymfonix
Sponsors & Partners 2020
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Erasmus MC
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Gemeente Rotterdam
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Life Sciences & Health 010
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AXON Lawyers
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