Innovation for Health - 14 February 2019
Global Investor Forum Contact
LinkedIn
Twitter
Facebook
Innovation for Health - Shaping the future of healthcare
Innovation for Health - Shaping the future of healthcare
Innovation for Health - Shaping the future of healthcare
Innovation for Health - Shaping the future of healthcare

Peter de Keizer

Group Leader “Senescence in Cancer and Aging”, UMC Utrecht

Session

14:15 - 15:25 hours
From research to innovation

Peter de Keizer received his PhD from Utrecht University Medical Center in 2009 for his work on FOXO transcription factors in tumor suppression. He received his postdoctoral training at the Buck Institute for Research on Aging in Novato, CA, USA on the molecular hallmarks of cellular senescence for which in 2010, he was elected as a fellow of the Dutch Cancer Society (KWF). In 2012 he joined the Erasmus University Medical Center in Rotterdam where in 2014 he was awarded the prestigious “Talent Extraordinary Award” and is currently a group leader in “Senescence in Cancer in Aging”

His research focusses on targeting the deleterious role of senescent cells. Senescence has been causally linked to age-related diseases, including cancer progression and therapy resistance. He designed a cell penetrating peptide, called FOXO4-DRI or Proxofim, which selectively eliminates senescent cells and thereby can counter signs of chemotoxicity and aging in mice. This work was published in Cell in March 2017 and received numerous exposure worldwide, including coverage in TV shows and radio programs. His current focus lies on further optimizing this peptide and assessing the potential benefit such compounds may have on late stage cancer and specific age-related diseases. His aim is to take an active stance in promoting clinical translation when the results prove to be fruitful.

Abstract

Targeting Senescence Against aging and Cancer
Senescent cells are a cause for certain aspects of aging and can confer resistance of cancer cells to therapy. As we showed recently (Baar et al, 2017, Cell), FOXO4 is a pivot in the maintenance of senescent cells viability and targeting the FOXO4-p53 pathway with specific peptides can result in health benefits in aging mice. Our goal is to improve these compounds to eventually be ready for human translation, specifically against lethal types of cancer.

Henk van Houten
Royal Philips

Henk van Houten
Edwin Moses
Ablynx
Edwin Moses

Peter Paul van Benthem
Dutch Association of Medical Specialists

Peter Paul van Benthem
Niels Chavannes
LUMC
Niels Chavannes

Madelon Maurice
UMC Utrecht & Oncode Institute

Madelon Maurice
Ingmar de Gooijer
myTomorrows
Ingmar de Gooijer
Tom Miller
GreyBird Ventures
Tom Miller
Mark van Houdenhoven
Sint Maartenskliniek
Mark van Houdenhoven
Ruben Kok
Dutch Techcentre for Life Sciences
Ruben Kok
Colja Laane
Mibiton
Colja Laane

Arthur Lahr
Kiadis Pharma

Arthur Lahr
Eveliene Manten-Horst
AYA Jongvolwassen & Kanker
Eveliene Manten-Horst
Kas Maessen
NWO Grootschalig Infrastructuur
Kas Maessen
Eline Vrijland-van Beest
NightBalance
Eline Vrijland-van Beest
Jos Malda
UMC Utrecht
Jos Malda
Lucien Hordijk
Journalist
Maarten van Dongen
LabForRent
Maarten van Dongen
Kees Recourt
Mibiton Foundation
Kees Recourt

Maurits van Selms
ACTA

Maurits Selms
Marianne van der Steen
MERLN
Marianne van der Steen
Werner Verbiest
Janssen Diagnostics
Werner Verbiest
Markwin Velders
Kite Pharma
Markwin Velders
Nicolas Vergauwe
miDiagnostics
Nicolas Vergauwe

Marc Schellekens
LabHotel Rotterdam

Marc Schellekens
Bert-Arjan Millenaar
NLC The Healthtec Venture Builder
Bert-Arjan Millenaar
Phil L'Huillier
MSD
Jeff Gielen
Kadans Science Partner
Jeff Gielen
Annemiek Verkamman
HollandBIO
Ton van der Steen
Erasmus MC Medical Delta
Hans Schikan
Health~Holland
Joep de Groot
CbusineZ
Joep de Groot
Peter Hinssen
nexxworks
Sponsors & Partners
Main partner
Health~Holland
Host sponsor
Erasmus MC
Host sponsor
Gemeente Rotterdam
Host sponsor
Life Sciences & Health 010
Platinum sponsor
Janssen Diagnostics - Janssen
Gold sponsor
Medical Delta
Silver sponsor
NLC The Healthtec Venture Builder
Sponsor
Kempen
Partner
Vereniging Innovatieve Geneesmiddelen
Partner
Global Investor Forum
Your logo?
Become a sponsor of Innovation for Health 2019!
© 2018 Innovation for Health